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PANEL 18 SFGU=Y
Wellcome Library, London
This is a medium power view of a section of trachea showing complete necrosis of the surface epithelium which has been replaced by a pseudomembrane of fibrin, necrotic cells and bacteria. From a case of diphtheria. H&E stain.
Formation of a thick grey membrane over the tonsils and throat is characteristic of nasopharyngeal diphtheria and is potentially fatal. Release of the diphtheria toxin from <I>Corynebacterium diphtheriae</I> causes necrosis of the epithelium. An inflammatory reaction causes exudation of fluid and leucocytes. This fluid clots and grips the dead cells within it forming a false membrane.
Mid 20th century
Collection: Wellcome Images
Copyrighted work available under Creative Commons by-nc 2.0 UK: England &
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